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An Alkyne-functionalized Arginine for Solid-Phase Synthesis Enabling “Bioorthogonal” Peptide Conjugation

[Image: see text] Lately, amino-functionalized N(ω)-carbamoylated arginines were introduced as arginine surrogates enabling peptide labeling. However, this approach is hardly compatible with peptides also containing lysine or cysteine. Here, we present the synthesis of an alkyne-functionalized, N(ω)...

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מידע ביבליוגרפי
הוצא לאור ב:ACS Med Chem Lett
Main Authors: Spinnler, Katrin, von Krüchten, Lara, Konieczny, Adam, Schindler, Lisa, Bernhardt, Günther, Keller, Max
פורמט: Artigo
שפה:Inglês
יצא לאור: American Chemical Society 2019
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7073887/
https://ncbi.nlm.nih.gov/pubmed/32184966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00388
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