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Design of Dual Inhibitors of Soluble Epoxide Hydrolase and LTA(4) Hydrolase
[Image: see text] Multitarget anti-inflammatory drugs interfering with the arachidonic acid cascade exhibit superior efficacy. In this study, a prototype dual inhibitor of soluble epoxide hydrolase (sEH) and LTA(4) hydrolase (LTA(4)H) with submicromolar activity toward both targets has been designed...
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| Veröffentlicht in: | ACS Med Chem Lett |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American
Chemical Society
2019
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7073873/ https://ncbi.nlm.nih.gov/pubmed/32184960 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00330 |
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