Design of Dual Inhibitors of Soluble Epoxide Hydrolase and LTA(4) Hydrolase

[Image: see text] Multitarget anti-inflammatory drugs interfering with the arachidonic acid cascade exhibit superior efficacy. In this study, a prototype dual inhibitor of soluble epoxide hydrolase (sEH) and LTA(4) hydrolase (LTA(4)H) with submicromolar activity toward both targets has been designed...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:ACS Med Chem Lett
Autores principales: Hiesinger, Kerstin, Schott, Annika, Kramer, Jan S., Blöcher, René, Witt, Finja, Wittmann, Sandra K., Steinhilber, Dieter, Pogoryelov, Denys, Gerstmeier, Jana, Werz, Oliver, Proschak, Ewgenij
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2019
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7073873/
https://ncbi.nlm.nih.gov/pubmed/32184960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00330
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares