Design, Synthesis and Cellular Characterization of a Dual Inhibitor of 5-Lipoxygenase and Soluble Epoxide Hydrolase

The arachidonic acid cascade is a key player in inflammation, and numerous well-established drugs interfere with this pathway. Previous studies have suggested that simultaneous inhibition of 5-lipoxygenase (5-LO) and soluble epoxide hydrolase (sEH) results in synergistic anti-inflammatory effects. I...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Meirer, Karin, Glatzel, Daniel, Kretschmer, Simon, Wittmann, Sandra K., Hartmann, Markus, Blöcher, René, Angioni, Carlo, Geisslinger, Gerd, Steinhilber, Dieter, Hofmann, Bettina, Fürst, Robert, Proschak, Ewgenij
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2016
Assuntos:
Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6155600/
https://ncbi.nlm.nih.gov/pubmed/28036068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22010045
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