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Development of Multitarget Agents Possessing Soluble Epoxide Hydrolase Inhibitory Activity

Over the last two decades polypharmacology has emerged as a new paradigm in drug discovery, even though developing drugs with high potency and selectivity toward a single biological target is still a major strategy. Often, targeting only a single enzyme or receptor shows lack of efficacy. High level...

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Vydáno v:Prostaglandins Other Lipid Mediat
Hlavní autoři: Hiesinger, Kerstin, Wagner, Karen M., Hammock, Bruce D., Proschak, Ewgenij, Hwang, Sung Hee
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6345559/
https://ncbi.nlm.nih.gov/pubmed/30593866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.prostaglandins.2018.12.003
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