Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain

The emerging pharmacological target soluble epoxide hydrolase (sEH) is a bifunctional enzyme exhibiting two different catalytic activities that are located in two distinct domains. Although the physiological role of the C-terminal hydrolase domain is well-investigated, little is known about its phos...

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Pubblicato in:J Med Chem
Autori principali: Kramer, Jan S., Woltersdorf, Stefano, Duflot, Thomas, Hiesinger, Kerstin, Lillich, Felix F., Knöll, Felix, Wittmann, Sandra K., Klingler, Franca-M., Brunst, Steffen, Chaikuad, Apirat, Morisseau, Christophe, Hammock, Bruce D., Buccellati, Carola, Sala, Angelo, Rovati, G. Enrico, Leuillier, Matthieu, Fraineau, Sylvain, Rondeaux, Julie, Hernandez-Olmos, Victor, Heering, Jan, Merk, Daniel, Pogoryelov, Denys, Steinhilber, Dieter, Knapp, Stefan, Bellien, Jeremy, Proschak, Ewgenij
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7262789/
https://ncbi.nlm.nih.gov/pubmed/31436984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00445
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