Compartmental analysis of T cell clonal dynamics as a function of pathologic response to neoadjuvant PD-1 blockade in resectable non-small cell lung cancer

PURPOSE: Neoadjuvant PD-1 blockade is a promising treatment for resectable non-small cell lung cancer (NSCLC), yet immunological mechanisms contributing to tumor regression and biomarkers of response are unknown. Using paired tumor/blood samples from a phase 2 clinical trial (NCT02259621), we explor...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Zhang, Jiajia, Ji, Zhicheng, Caushi, Justina X., El Asmar, Margueritta, Anagnostou, Valsamo, Cottrell, Tricia R., Chan, Hok Yee, Suri, Prerna, Guo, Haidan, Merghoub, Taha, Chaft, Jamie E., Reuss, Joshua E., Tam, Ada, Blosser, Richard, Abu-Akeel, Mohsen, Sidhom, John-William, Zhao, Ni, Ha, Jinny S., Jones, David R., Marrone, Kristen A., Naidoo, Jarushka, Gabrielson, Edward, Taube, Janis M., Velculescu, Victor E., Brahmer, Julie R., Housseau, Franck, Hellmann, Matthew D., Forde, Patrick M., Pardoll, Drew M., Ji, Hongkai, Smith, Kellie N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7073288/
https://ncbi.nlm.nih.gov/pubmed/31754049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-2931
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