Dual PI3K/mTOR Inhibitor NVP-BEZ235 Enhances Radiosensitivity of Head and Neck Squamous Cell Carcinoma (HNSCC) Cell Lines Due to Suppressed Double-Strand Break (DSB) Repair by Non-Homologous End Joining

The PI3K/Akt/mTOR pathway is frequently altered in human papillomavirus (HPV)-positive and negative squamous cell carcinoma of the head and neck (HNSCC) and overstimulation is associated with poor prognosis. PI3K drives Akt activation and constitutive signaling acts pro-proliferative, supports cell...

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Udgivet i:Cancers (Basel)
Main Authors: Schötz, Ulrike, Balzer, Viola, Brandt, Friedrich-Wilhelm, Ziemann, Frank, Subtil, Florentine S.B., Rieckmann, Thorsten, Köcher, Sabrina, Engenhart-Cabillic, Rita, Dikomey, Ekkehard, Wittig, Andrea, Arenz, Andrea
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7072694/
https://ncbi.nlm.nih.gov/pubmed/32085396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12020467
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