Dactolisib (NVP-BEZ235) toxicity in murine brain tumour models

BACKGROUND: Glioblastomas (GBMs) are highly malignant brain tumours with a poor prognosis, and current cytotoxic regimens provide only a limited survival benefit. The PI3K/Akt/mTOR pathway has been an attractive target for therapy due to its high activation in GBMs as well as other cancers. The dual...

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Vydáno v:BMC Cancer
Hlavní autoři: Netland, I. A., Førde, H. E., Sleire, L., Leiss, L., Rahman, M. A., Skeie, B. S., Gjerde, C. H., Enger, P. Ø., Goplen, D.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4992256/
https://ncbi.nlm.nih.gov/pubmed/27542970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2712-4
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