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Dactolisib (NVP-BEZ235) toxicity in murine brain tumour models
BACKGROUND: Glioblastomas (GBMs) are highly malignant brain tumours with a poor prognosis, and current cytotoxic regimens provide only a limited survival benefit. The PI3K/Akt/mTOR pathway has been an attractive target for therapy due to its high activation in GBMs as well as other cancers. The dual...
Sparad:
I publikationen: | BMC Cancer |
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Huvudupphovsmän: | , , , , , , , , |
Materialtyp: | Artigo |
Språk: | Inglês |
Publicerad: |
BioMed Central
2016
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Ämnen: | |
Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4992256/ https://ncbi.nlm.nih.gov/pubmed/27542970 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2712-4 |
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