Neuroprotective effects of the anticancer drug NVP-BEZ235 (dactolisib) on amyloid-β 1–42 induced neurotoxicity and memory impairment

Alzheimer’s Disease (AD) is a progressive neurodegenerative disease and the main cause of dementia. Substantial evidences indicate that there is over-activation of the PI3K/Akt/mTOR axis in AD. Therefore, the aim of the present study was to investigate the effects of NVP-BEZ235 (BEZ; dactolisib), a...

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Publicado no:Sci Rep
Main Authors: Bellozi, Paula Maria Quaglio, Lima, Isabel Vieira de Assis, Dória, Juliana Guimarães, Vieira, Érica Leandro Marciano, Campos, Alline Cristina, Candelario-Jalil, Eduardo, Reis, Helton José, Teixeira, Antônio Lúcio, Ribeiro, Fabíola Mara, de Oliveira, Antônio Carlos Pinheiro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855228/
https://ncbi.nlm.nih.gov/pubmed/27142962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25226
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