Treatment with the PI3K inhibitor buparlisib (NVP-BKM120) suppresses the growth of established patient-derived GBM xenografts and prolongs survival in nude rats

Glioblastomas (GBMs) are aggressive brain tumours with a dismal prognosis, despite combined surgery, radio- and chemotherapy. Close to 90 % of all GBMs harbour a deregulated PI3K pathway, which is essential in regulating central cellular functions such as proliferation, cell growth, motility and sur...

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Detalhes bibliográficos
Publicado no:J Neurooncol
Main Authors: Netland, I. A., Førde, H. E., Sleire, L., Leiss, L., Rahman, M. A., Skeie, B. S., Miletic, H., Enger, P. Ø., Goplen, D.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2016
Assuntos:
Laboratory Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4972854/
https://ncbi.nlm.nih.gov/pubmed/27283525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-016-2158-1
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