RNF90 negatively regulates cellular antiviral responses by targeting MITA for degradation

Mediator of IRF3 activation (MITA, also named as STING/ERIS/MPYS/TMEM173), is essential to DNA virus- or cytosolic DNA-triggered innate immune responses. In this study, we demonstrated the negative regulatory role of RING-finger protein (RNF) 90 in innate immune responses targeting MITA. RNF90 promo...

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Bibliografske podrobnosti
izdano v:PLoS Pathog
Main Authors: Yang, Bo, Liu, Yue, Cui, Yuhan, Song, Di, Zhang, Ge, Ma, Shujun, Liu, Yanzi, Chen, Mengmeng, Chen, Fan, Wang, Hui, Wang, Jie
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2020
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7069649/
https://ncbi.nlm.nih.gov/pubmed/32126128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008387
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