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FoxO1 Negatively Regulates Cellular Antiviral Response by Promoting Degradation of IRF3

Viral infection causes activation of the transcription factor IRF3, which is critical for production of type I interferons (IFNs) and innate antiviral immune response. How virus-induced type I IFN signaling is controlled is not fully understood. Here we identified the transcription factor FoxO1 as a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Lei, Cao-Qi, Zhang, Yu, Xia, Tian, Jiang, Li-Qun, Zhong, Bo, Shu, Hong-Bing
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3642307/
https://ncbi.nlm.nih.gov/pubmed/23532851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.444794
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