RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA

MAVS and MITA are essential adaptor proteins mediating innate antiviral immune responses against RNA and DNA viruses, respectively. Here we show that RNF115 plays dual roles in response to RNA or DNA virus infections by catalyzing distinct types of ubiquitination of MAVS and MITA at different phases...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Zhang, Zhi-Dong, Xiong, Tian-Chen, Yao, Shu-Qi, Wei, Ming-Cong, Chen, Ming, Lin, Dandan, Zhong, Bo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7606512/
https://ncbi.nlm.nih.gov/pubmed/33139700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19318-3
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