Pre-existing antitherapeutic antibodies against the Fc region of the hu14.18K322A mAb are associated with outcome in patients with relapsed neuroblastoma

PURPOSE: Patients with cancer receiving tumor-reactive humanized monoclonal antibody (mAb) therapy can develop a human antihuman antibody (HAHA) response against the therapeutic mAb. We evaluated for HAHA in patients with neuroblastoma treated in a phase I study of humanized anti-GD2 mAb (immunoglob...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Goldberg, Jacob L, Navid, Fariba, Hank, Jacquelyn A, Erbe, Amy K, Santana, Victor, Gan, Jacek, de Bie, Fenna, Javaid, Amal M, Hoefges, Anna, Merdler, Michael, Carmichael, Lakeesha, Kim, KyungMann, Bishop, Michael W, Meager, Michael M, Gillies, Stephen D, Pandey, Janardan P, Sondel, Paul M
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2020
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7069273/
https://ncbi.nlm.nih.gov/pubmed/32169872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-000590
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