Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy

Cancer chemotherapy targeting frequent loss of heterozygosity events is an attractive concept, since tumor cells may lack enzymatic activities present in normal constitutional cells. To find exploitable targets, we map prevalent genetic polymorphisms to protein structures and identify 45 nsSNVs (non...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Rendo, Veronica, Stoimenov, Ivaylo, Mateus, André, Sjöberg, Elin, Svensson, Richard, Gustavsson, Anna-Lena, Johansson, Lars, Ng, Adrian, OʼBrien, Casey, Giannakis, Marios, Artursson, Per, Nygren, Peter, Cheong, Ian, Sjöblom, Tobias
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7066191/
https://ncbi.nlm.nih.gov/pubmed/32161261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15111-4
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