Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy

Cancer chemotherapy targeting frequent loss of heterozygosity events is an attractive concept, since tumor cells may lack enzymatic activities present in normal constitutional cells. To find exploitable targets, we map prevalent genetic polymorphisms to protein structures and identify 45 nsSNVs (non...

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Rendo, Veronica, Stoimenov, Ivaylo, Mateus, André, Sjöberg, Elin, Svensson, Richard, Gustavsson, Anna-Lena, Johansson, Lars, Ng, Adrian, OʼBrien, Casey, Giannakis, Marios, Artursson, Per, Nygren, Peter, Cheong, Ian, Sjöblom, Tobias
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2020
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7066191/
https://ncbi.nlm.nih.gov/pubmed/32161261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15111-4
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