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Defining eligible patients for allele-selective chemotherapies targeting NAT2 in colorectal cancer

Therapies targeting somatic bystander genetic events represent a new avenue for cancer treatment. We recently identified a subset of colorectal cancer (CRC) patients who are heterozygous for a wild-type and a low activity allele (NAT2*6) but lack the wild-type allele in their tumors due to loss of h...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Rendo, Veronica, Kundu, Snehangshu, Rameika, Natallia, Ljungström, Viktor, Svensson, Richard, Palin, Kimmo, Aaltonen, Lauri, Stoimenov, Ivaylo, Sjöblom, Tobias
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7775439/
https://ncbi.nlm.nih.gov/pubmed/33384440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-80288-z
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