Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy

The integrated stress response (ISR) converges on eIF2α phosphorylation to regulate protein synthesis. ISR is activated by several stress conditions, including endoplasmic reticulum (ER) stress, executed by protein kinase R-like endoplasmic reticulum kinase (PERK). We report that ER stress combined...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Mahameed, Mohamed, Boukeileh, Shatha, Obiedat, Akram, Darawshi, Odai, Dipta, Priya, Rimon, Amit, McLennan, Gordon, Fassler, Rosi, Reichmann, Dana, Karni, Rotem, Preisinger, Christian, Wilhelm, Thomas, Huber, Michael, Tirosh, Boaz
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7066181/
https://ncbi.nlm.nih.gov/pubmed/32161259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15067-5
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