Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy

The integrated stress response (ISR) converges on eIF2α phosphorylation to regulate protein synthesis. ISR is activated by several stress conditions, including endoplasmic reticulum (ER) stress, executed by protein kinase R-like endoplasmic reticulum kinase (PERK). We report that ER stress combined...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Mahameed, Mohamed, Boukeileh, Shatha, Obiedat, Akram, Darawshi, Odai, Dipta, Priya, Rimon, Amit, McLennan, Gordon, Fassler, Rosi, Reichmann, Dana, Karni, Rotem, Preisinger, Christian, Wilhelm, Thomas, Huber, Michael, Tirosh, Boaz
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7066181/
https://ncbi.nlm.nih.gov/pubmed/32161259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15067-5
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