The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors

IRE1, PERK, and ATF6 are the three transducers of the mammalian canonical unfolded protein response (UPR). GSK2606414 is a potent inhibitor of PERK, while KIRA6 inhibits the kinase activity of IRE1. Both molecules are frequently used to probe the biological roles of the UPR in mammalian cells. In a...

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Udgivet i:Cell Death Dis
Main Authors: Mahameed, Mohamed, Wilhelm, Thomas, Darawshi, Odai, Obiedat, Akram, Tommy, Weiss-Sadan, Chintha, Chetan, Schubert, Thomas, Samali, Afshin, Chevet, Eric, Eriksson, Leif A., Huber, Michael, Tirosh, Boaz
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6443726/
https://ncbi.nlm.nih.gov/pubmed/30931942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1523-3
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