Picolinic Acid, a Tryptophan Oxidation Product, does not Impact Bone Mineral Density but Increases Marrow Adiposity

Tryptophan is an essential amino acid catabolized initially to kynurenine (kyn), an immunomodulatory metabolite that we have previously shown to promote bone loss. Kyn levels increase with aging and have also been associated with neurodegenerative disorders. Picolinic acid (PA) is another tryptophan...

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Udgivet i:Exp Gerontol
Main Authors: Ding, Kehong, McGee-Lawrence, Meghan E., Kaiser, Helen, Sharma, Anuj K., Pierce, Jessica L., Irsik, Debra L., Bollag, Wendy B., Xu, Jianrui, Zhong, Qing, Hill, William, Shi, Xing-Ming, Fulzele, Sadanand, Kennedy, Eileen J., Elsalanty, Mohammed, Hamrick, Mark W., Isales, Carlos M.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7065047/
https://ncbi.nlm.nih.gov/pubmed/32088397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exger.2020.110885
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