Optimized Inhibitors of MDM2 via an Attempted Protein‐Templated Reductive Amination

Innovative and efficient hit‐identification techniques are required to accelerate drug discovery. Protein‐templated fragment ligations represent a promising strategy in early drug discovery, enabling the target to assemble and select its binders from a pool of building blocks. Development of new pro...

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Udgivet i:ChemMedChem
Main Authors: van der Vlag, Ramon, Yagiz Unver, M., Felicetti, Tommaso, Twarda‐Clapa, Aleksandra, Kassim, Fatima, Ermis, Cagdas, Neochoritis, Constantinos G., Musielak, Bogdan, Labuzek, Beata, Dömling, Alexander, Holak, Tad A., Hirsch, Anna K. H.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7064911/
https://ncbi.nlm.nih.gov/pubmed/31774938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201900574
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