A carregar...
Scaffold hopping via ANCHOR.QUERY: β-lactams as potent p53-MDM2 antagonists
Using the pharmacophore-based virtual screening platform ANCHOR.QUERY, we morphed our recently described Ugi-4CR scaffold towards a β-lactam scaffold with potent p53-MDM2 antagonizing activities. 2D-HSQC and FP measurements confirm potent MDM2 binding. Molecular modeling studies were used to underst...
Na minha lista:
| Publicado no: | Medchemcomm |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2017
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5637554/ https://ncbi.nlm.nih.gov/pubmed/29034069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00058h |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|