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Scaffold hopping via ANCHOR.QUERY: β-lactams as potent p53-MDM2 antagonists
Using the pharmacophore-based virtual screening platform ANCHOR.QUERY, we morphed our recently described Ugi-4CR scaffold towards a β-lactam scaffold with potent p53-MDM2 antagonizing activities. 2D-HSQC and FP measurements confirm potent MDM2 binding. Molecular modeling studies were used to underst...
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| הוצא לאור ב: | Medchemcomm |
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| Main Authors: | , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Royal Society of Chemistry
2017
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5637554/ https://ncbi.nlm.nih.gov/pubmed/29034069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00058h |
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