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Design of indole- and MCR-based macrocycles as p53-MDM2 antagonists
Macrocycles were designed to antagonize the protein–protein interaction p53-MDM2 based on the three-finger pharmacophore F(19)W(23)L(25). The synthesis was accomplished by a rapid, one-pot synthesis of indole-based macrocycles based on Ugi macrocyclization. The reaction of 12 different α,ω-amino aci...
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| Publicado no: | Beilstein J Org Chem |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Beilstein-Institut
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6404402/ https://ncbi.nlm.nih.gov/pubmed/30873235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.15.45 |
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