Hitting on the move: Targeting intrinsically disordered protein states of the MDM2-p53 interaction

Intrinsically disordered proteins are an emerging class of proteins without a folded structure and currently disorder-based drug targeting remains a challenge. p53 is the principal regulator of cell division and growth whereas MDM2 consists its main negative regulator. The MDM2-p53 recognition is a...

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Dades bibliogràfiques
Publicat a:Eur J Med Chem
Autors principals: Neochoritis, Constantinos G., Atmaj, Jack, Twarda-Clapa, Aleksandra, Surmiak, Ewa, Skalniak, Lukasz, Köhler, Lisa-Maria, Muszak, Damian, Kurpiewska, Katarzyna, Kalinowska-Tłuścik, Justyna, Beck, Barbara, Holak, Tad A., Dömling, Alexander
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7008132/
https://ncbi.nlm.nih.gov/pubmed/31421630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2019.111588
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