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Hitting on the move: Targeting intrinsically disordered protein states of the MDM2-p53 interaction
Intrinsically disordered proteins are an emerging class of proteins without a folded structure and currently disorder-based drug targeting remains a challenge. p53 is the principal regulator of cell division and growth whereas MDM2 consists its main negative regulator. The MDM2-p53 recognition is a...
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| הוצא לאור ב: | Eur J Med Chem |
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| Main Authors: | , , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2019
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7008132/ https://ncbi.nlm.nih.gov/pubmed/31421630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2019.111588 |
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