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BET protein inhibitor JQ1 downregulates chromatin accessibility and suppresses metastasis of gastric cancer via inactivating RUNX2/NID1 signaling
Chromatin accessibility is critical for tumor development, whose mechanisms remain unclear. As a crucial regulator for chromatin remodeling, BRD4 promotes tumor progression by regulating multiple genes. As a small-molecule inhibitor of BRD4, JQ1 has potent chemotherapeutic activity against various h...
שמור ב:
הוצא לאור ב: | Oncogenesis |
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Main Authors: | , , , , , , , , , , , , , , , |
פורמט: | Artigo |
שפה: | Inglês |
יצא לאור: |
Nature Publishing Group UK
2020
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נושאים: | |
גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7064486/ https://ncbi.nlm.nih.gov/pubmed/32157097 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-020-0218-z |
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