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The BET-bromodomain inhibitor JQ1 mitigates vemurafenib drug resistance in melanoma

Inhibition of BRAF improves therapeutic efficacy of BRAF-mutant melanoma. However, drug resistance to BRAF inhibitor is inevitable, and the drug resistance mechanisms still remain to be elucidated. Here, BRAF(V600E) mutant cells A375 and SK-MEL-28 were chosen and treated with BRAF inhibitor vemurafe...

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Detalhes bibliográficos
Publicado no:Melanoma Res
Main Authors: Zhao, Bei, Cheng, Xiankui, Zhou, Xiyuan
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6221393/
https://ncbi.nlm.nih.gov/pubmed/30192303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CMR.0000000000000497
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