A benchmark of algorithms for the analysis of pooled CRISPR screens

Genome-wide pooled CRISPR-Cas-mediated knockout, activation, and repression screens are powerful tools for functional genomic investigations. Despite their increasing importance, there is currently little guidance on how to design and analyze CRISPR-pooled screens. Here, we provide a review of the c...

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Bibliographic Details
Published in:Genome Biol
Main Authors: Bodapati, Sunil, Daley, Timothy P., Lin, Xueqiu, Zou, James, Qi, Lei S.
Format: Artigo
Language:Inglês
Published: BioMed Central 2020
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7063732/
https://ncbi.nlm.nih.gov/pubmed/32151271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-01972-x
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