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Kinetics of CXCL12 binding to atypical chemokine receptor 3 reveal a role for the receptor N-terminus in chemokine binding

Chemokines bind to membrane-spanning chemokine receptors, which signal through G proteins and promote cell migration. However, the atypical chemokine receptor 3 (ACKR3) does not appear to couple to G proteins and instead of directly promoting cell migration, it regulates the extracellular concentrat...

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Vydáno v:Sci Signal
Hlavní autoři: Gustavsson, Martin, Dyer, Douglas P., Zhao, Chunxia, Handel, Tracy M
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7063449/
https://ncbi.nlm.nih.gov/pubmed/31506383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaw3657
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