Individualized genetic network analysis reveals new therapeutic vulnerabilities in 6,700 cancer genomes

Tumor-specific genomic alterations allow systematic identification of genetic interactions that promote tumorigenesis and tumor vulnerabilities, offering novel strategies for development of targeted therapies for individual patients. We develop an Individualized Network-based Co-Mutation (INCM) meth...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Liu, Chuang, Zhao, Junfei, Lu, Weiqiang, Dai, Yao, Hockings, Jennifer, Zhou, Yadi, Nussinov, Ruth, Eng, Charis, Cheng, Feixiong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7062285/
https://ncbi.nlm.nih.gov/pubmed/32101536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007701
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