Proteogenomic characterization reveals therapeutic vulnerabilities in lung adenocarcinoma

To explore the biology of lung adenocarcinoma (LUAD) and identify new therapeutic opportunities, we performed comprehensive proteogenomic characterization of 110 tumors and 101 matched normal adjacent tissues (NATs) incorporating genomics, epigenomics, deep-scale proteomics, phosphoproteomics and ac...

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Publicado no:Cell
Main Authors: Gillette, Michael A., Satpathy, Shankha, Cao, Song, Dhanasekaran, Saravana M., Vasaikar, Suhas V., Krug, Karsten, Petralia, Francesca, Li, Yize, Liang, Wen-Wei, Reva, Boris, Krek, Azra, Ji, Jiayi, Song, Xiaoyu, Liu, Wenke, Hong, Runyu, Yao, Lijun, Blumenberg, Lili, Savage, Sara R., Wendl, Michael C., Wen, Bo, Li, Kai, Tang, Lauren C., MacMullan, Melanie A., Avanessian, Shayan C., Kane, M. Harry, Newton, Chelsea J., Cornwell, MacIntosh, Kothadia, Ramani B., Ma, Weiping, Yoo, Seungyeul, Mannan, Rahul, Vats, Pankaj, Kumar-Sinha, Chandan, Kawaler, Emily A., Omelchenko, Tatiana, Colaprico, Antonio, Geffen, Yifat, Maruvka, Yosef E., da Veiga Leprevost, Felipe, Wiznerowicz, Maciej, Gümüs, Zeynep H., Veluswamy, Rajwanth R., Hostetter, Galen, Heiman, David I., Wyczalkowski, Matthew A., Hiltke, Tara, Mesri, Mehdi, Kinsinger, Christopher R., Boja, Emily S., Omenn, Gilbert S., Chinnaiyan, Arul M., Rodriguez, Henry, Li, Qing Kay, Jewell, Scott D., Thiagarajan, Mathangi, Getz, Gad, Zhang, Bing, Fenyö, David, Ruggles, Kelly V., Cieslik, Marcin P., Robles, Ana I., Clauser, Karl R., Govindan, Ramaswamy, Wang, Pei, Nesvizhskii, Alexey I., Ding, Li, Mani, D. R., Carr, Steven A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7373300/
https://ncbi.nlm.nih.gov/pubmed/32649874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.06.013
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