Individualized genetic network analysis reveals new therapeutic vulnerabilities in 6,700 cancer genomes

Tumor-specific genomic alterations allow systematic identification of genetic interactions that promote tumorigenesis and tumor vulnerabilities, offering novel strategies for development of targeted therapies for individual patients. We develop an Individualized Network-based Co-Mutation (INCM) meth...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:PLoS Comput Biol
मुख्य लेखकों: Liu, Chuang, Zhao, Junfei, Lu, Weiqiang, Dai, Yao, Hockings, Jennifer, Zhou, Yadi, Nussinov, Ruth, Eng, Charis, Cheng, Feixiong
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Public Library of Science 2020
विषय:
Research Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC7062285/
https://ncbi.nlm.nih.gov/pubmed/32101536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007701
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