Individualized genetic network analysis reveals new therapeutic vulnerabilities in 6,700 cancer genomes

Tumor-specific genomic alterations allow systematic identification of genetic interactions that promote tumorigenesis and tumor vulnerabilities, offering novel strategies for development of targeted therapies for individual patients. We develop an Individualized Network-based Co-Mutation (INCM) meth...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS Comput Biol
Auteurs principaux: Liu, Chuang, Zhao, Junfei, Lu, Weiqiang, Dai, Yao, Hockings, Jennifer, Zhou, Yadi, Nussinov, Ruth, Eng, Charis, Cheng, Feixiong
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2020
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7062285/
https://ncbi.nlm.nih.gov/pubmed/32101536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007701
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