Individualized genetic network analysis reveals new therapeutic vulnerabilities in 6,700 cancer genomes

Tumor-specific genomic alterations allow systematic identification of genetic interactions that promote tumorigenesis and tumor vulnerabilities, offering novel strategies for development of targeted therapies for individual patients. We develop an Individualized Network-based Co-Mutation (INCM) meth...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:PLoS Comput Biol
Main Authors: Liu, Chuang, Zhao, Junfei, Lu, Weiqiang, Dai, Yao, Hockings, Jennifer, Zhou, Yadi, Nussinov, Ruth, Eng, Charis, Cheng, Feixiong
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2020
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7062285/
https://ncbi.nlm.nih.gov/pubmed/32101536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007701
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