Conditional KCa3.1-transgene induction in murine skin produces pruritic eczematous dermatitis with severe epidermal hyperplasia and hyperkeratosis

Ion channels have recently attracted attention as potential mediators of skin disease. Here, we explored the consequences of genetically encoded induction of the cell volume-regulating Ca(2+)-activated KCa3.1 channel (Kcnn4) for murine epidermal homeostasis. Doxycycline-treated mice harboring the KC...

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Publicado en:PLoS One
Main Authors: Lozano-Gerona, Javier, Oliván-Viguera, Aida, Delgado-Wicke, Pablo, Singh, Vikrant, Brown, Brandon M., Tapia-Casellas, Elena, Pueyo, Esther, Valero, Marta Sofía, Garcia-Otín, Ángel-Luis, Giraldo, Pilar, Abarca-Lachen, Edgar, Surra, Joaquín C., Osada, Jesús, Hamilton, Kirk L., Raychaudhuri, Siba P., Marigil, Miguel, Juarranz, Ángeles, Wulff, Heike, Miura, Hiroto, Gilaberte, Yolanda, Köhler, Ralf
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2020
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7062274/
https://ncbi.nlm.nih.gov/pubmed/32150577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0222619
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