Inhibition of Intermediate-Conductance Calcium-Activated K Channel (KCa3.1) and Fibroblast Mitogenesis by α-Linolenic Acid and Alterations of Channel Expression in the Lysosomal Storage Disorders, Fabry Disease, and Niemann Pick C

The calcium/calmodulin-gated KCa3.1 channel regulates normal and abnormal mitogenesis by controlling K(+)-efflux, cell volume, and membrane hyperpolarization-driven calcium-entry. Recent studies suggest modulation of KCa3.1 by omega-3 fatty acids as negative modulators and impaired KCa3.1 functions...

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Detalles Bibliográficos
Publicado en:Front Physiol
Main Authors: Oliván-Viguera, Aida, Lozano-Gerona, Javier, López de Frutos, Laura, Cebolla, Jorge J., Irún, Pilar, Abarca-Lachen, Edgar, García-Malinis, Ana J., García-Otín, Ángel Luis, Gilaberte, Yolanda, Giraldo, Pilar, Köhler, Ralf
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2017
Assuntos:
Physiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5281581/
https://ncbi.nlm.nih.gov/pubmed/28197106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2017.00039
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