Conditional KCa3.1-transgene induction in murine skin produces pruritic eczematous dermatitis with severe epidermal hyperplasia and hyperkeratosis

Ion channels have recently attracted attention as potential mediators of skin disease. Here, we explored the consequences of genetically encoded induction of the cell volume-regulating Ca(2+)-activated KCa3.1 channel (Kcnn4) for murine epidermal homeostasis. Doxycycline-treated mice harboring the KC...

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מידע ביבליוגרפי
הוצא לאור ב:PLoS One
Main Authors: Lozano-Gerona, Javier, Oliván-Viguera, Aida, Delgado-Wicke, Pablo, Singh, Vikrant, Brown, Brandon M., Tapia-Casellas, Elena, Pueyo, Esther, Valero, Marta Sofía, Garcia-Otín, Ángel-Luis, Giraldo, Pilar, Abarca-Lachen, Edgar, Surra, Joaquín C., Osada, Jesús, Hamilton, Kirk L., Raychaudhuri, Siba P., Marigil, Miguel, Juarranz, Ángeles, Wulff, Heike, Miura, Hiroto, Gilaberte, Yolanda, Köhler, Ralf
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2020
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7062274/
https://ncbi.nlm.nih.gov/pubmed/32150577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0222619
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