Conditional KCa3.1-transgene induction in murine skin produces pruritic eczematous dermatitis with severe epidermal hyperplasia and hyperkeratosis

Ion channels have recently attracted attention as potential mediators of skin disease. Here, we explored the consequences of genetically encoded induction of the cell volume-regulating Ca(2+)-activated KCa3.1 channel (Kcnn4) for murine epidermal homeostasis. Doxycycline-treated mice harboring the KC...

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Udgivet i:PLoS One
Main Authors: Lozano-Gerona, Javier, Oliván-Viguera, Aida, Delgado-Wicke, Pablo, Singh, Vikrant, Brown, Brandon M., Tapia-Casellas, Elena, Pueyo, Esther, Valero, Marta Sofía, Garcia-Otín, Ángel-Luis, Giraldo, Pilar, Abarca-Lachen, Edgar, Surra, Joaquín C., Osada, Jesús, Hamilton, Kirk L., Raychaudhuri, Siba P., Marigil, Miguel, Juarranz, Ángeles, Wulff, Heike, Miura, Hiroto, Gilaberte, Yolanda, Köhler, Ralf
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7062274/
https://ncbi.nlm.nih.gov/pubmed/32150577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0222619
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