Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation

Stable inheritance of DNA methylation is critical for maintaining differentiated phenotypes in multicellular organisms. We have recently identified dual mono-ubiquitylation of histone H3 (H3Ub2) by UHRF1 as an essential mechanism to recruit DNMT1 to chromatin. Here, we show that PCNA-associated fact...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: Nishiyama, Atsuya, Mulholland, Christopher B., Bultmann, Sebastian, Kori, Satomi, Endo, Akinori, Saeki, Yasushi, Qin, Weihua, Trummer, Carina, Chiba, Yoshie, Yokoyama, Haruka, Kumamoto, Soichiro, Kawakami, Toru, Hojo, Hironobu, Nagae, Genta, Aburatani, Hiroyuki, Tanaka, Keiji, Arita, Kyohei, Leonhardt, Heinrich, Nakanishi, Makoto
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060239/
https://ncbi.nlm.nih.gov/pubmed/32144273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15006-4
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