Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX–DNMT3–DNMT3L domain

DNMT3 proteins are de novo DNA methyltransferases that are responsible for the establishment of DNA methylation patterns in mammalian genomes. Here, we have determined the crystal structures of the ATRX–DNMT3–DNMT3L (ADD) domain of DNMT3A in an unliganded form and in a complex with the amino-termina...

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Detalhes bibliográficos
Main Authors: Otani, Junji, Nankumo, Toshiyuki, Arita, Kyohei, Inamoto, Susumu, Ariyoshi, Mariko, Shirakawa, Masahiro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Scientific Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775176/
https://ncbi.nlm.nih.gov/pubmed/19834512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2009.218
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