Structural Basis of the Versatile DNA Recognition Ability of the Methyl-CpG Binding Domain of Methyl-CpG Binding Domain Protein 4

The methyl-CpG binding domain (MBD) protein MBD4 participates in DNA repair as a glycosylase that excises mismatched thymine bases in CpG sites and also functions in transcriptional repression. Unlike other MBD proteins, MBD4 recognizes not only methylated CpG dinucleotides ((5m)CG/(5m)CG) but also...

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Bibliographische Detailangaben
Hauptverfasser: Otani, Junji, Arita, Kyohei, Kato, Tsuyoshi, Kinoshita, Mariko, Kimura, Hironobu, Suetake, Isao, Tajima, Shoji, Ariyoshi, Mariko, Shirakawa, Masahiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
DNA and Chromosomes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585070/
https://ncbi.nlm.nih.gov/pubmed/23316048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.431098
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