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Solution structure of the methyl-CpG-binding domain of the methylation-dependent transcriptional repressor MBD1.
CpG methylation in vertebrates is important for gene silencing, alterations in chromatin structure and genomic stability, and differences in the DNA-methylation status are correlated with imprinting phenomena, carcinogenesis and embryonic development. Methylation signals are interpreted by protein f...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1171728/ https://ncbi.nlm.nih.gov/pubmed/10581239 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.23.6653 |
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