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Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX–DNMT3–DNMT3L domain
DNMT3 proteins are de novo DNA methyltransferases that are responsible for the establishment of DNA methylation patterns in mammalian genomes. Here, we have determined the crystal structures of the ATRX–DNMT3–DNMT3L (ADD) domain of DNMT3A in an unliganded form and in a complex with the amino-termina...
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Glavni autori: | , , , , , |
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Format: | Artigo |
Jezik: | Inglês |
Izdano: |
Nature Publishing Group
2009
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Teme: | |
Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2775176/ https://ncbi.nlm.nih.gov/pubmed/19834512 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2009.218 |
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