HPF1-dependent PARP activation promotes LIG3-XRCC1-mediated backup pathway of Okazaki fragment ligation

DNA ligase 1 (LIG1) is known as the major DNA ligase responsible for Okazaki fragment joining. Recent studies have implicated LIG3 complexed with XRCC1 as an alternative player in Okazaki fragment joining in cases where LIG1 is not functional, although the underlying mechanisms are largely unknown....

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Kumamoto, Soichiro, Nishiyama, Atsuya, Chiba, Yoshie, Miyashita, Ryota, Konishi, Chieko, Azuma, Yoshiaki, Nakanishi, Makoto
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2021
Témata:
Gene regulation, Chromatin and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8136790/
https://ncbi.nlm.nih.gov/pubmed/33872376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab269
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