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HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones
Upon binding to DNA breaks, poly(ADP-ribose) polymerase 1 (PARP1) ADP-ribosylates itself and other factors to initiate DNA repair. Serine is the major residue for ADP-ribosylation upon DNA damage, which strictly depends on HPF1. Here, we report the crystal structures of human HPF1/PARP1-CAT ΔHD comp...
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| Publicado en: | Nat Commun |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7884425/ https://ncbi.nlm.nih.gov/pubmed/33589610 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21302-4 |
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