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HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation
The anti-cancer drug target poly(ADP-ribose) polymerase 1 (PARP1) and its close homologue, PARP2, are early responders to DNA damage in human cells(1,2). Upon binding to genomic lesions, these enzymes utilise NAD(+) to modify a plethora of proteins with mono- and poly(ADP-ribose) signals that are im...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7104379/ https://ncbi.nlm.nih.gov/pubmed/32028527 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2013-6 |
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