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DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on protein substrates
Ubiquitylation had been considered limited to protein lysine residues, but other substrates have recently emerged. Here, we show that DELTEX E3 ligases specifically target the 3′ hydroxyl of the adenosine diphosphate (ADP)–ribosyl moiety that can be linked to a protein, thus generating a hybrid ADP-...
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| Izdano u: | Sci Adv |
|---|---|
| Glavni autori: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Association for the Advancement of Science
2022
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7615817/ https://ncbi.nlm.nih.gov/pubmed/36197986 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.add4253 |
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